tumor margin assessment

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Since the distance between sections determines the quality of the margin evaluation, the cost of this approach limits its use in veterinary medicine.A modified technique combines radial and parallel techniques (Fig. Schnabel F, Boolbol SK, Gittleman M, et al. The primary tumor was found intraoperatively on frozen sections in 82% (n = 50) of patients. 6: A3). A 2-6 mm full thickness plane/slab/piece will be cut from the cross section surface of the mass.our laboratory uses the “Cross Method” (i.e. Sign in using your membership username and password. A greater incidence of PSMs was found in Fuhrman 3/4 tumors Despite being highly specific, the sensitivity of tumor bed frozen section in NSS in predicting the presence of a PSM in the resected tumor has been shown to be only 30% Alternatives to intraoperative frozen section have also been developed and studied.

One of the main advantages of imprint cytology is its ability to assess the entire tumor surface rather than a specific area and it has been proven time‐ and cost‐effective Identification of breast cancer margins using …

Do not pour dye on the surface, but use the cotton swab or wooden applicator stick.

Current treatment options include the surgical removal of the lesion via breast-conserving surgery (lumpectomy) followed by irradiation or mastectomy.High-resolution, real-time OCT can be used to intraoperatively guide the surgical resection of solid tumors by identifying tumor margins and scanning for metastatic cells or distant foci of tumor cells.Photograph of the clinical spectral domain optical coherence tomography (SD-OCT) system housed in a standard medical endoscopy cart (left). The aim of intraoperative margin assessment is to evaluate the adequacy of tumor removal, also referred to as “margin assessment.” 1 Although the need for routine intraoperative margin assessment is engrained in the minds of surgeons and pathologists, the method of margin assessment is not universally agreed on. 5: A4).

Semin Diagn Pathol. Patients with PSMs were significantly older compared with those with negative margins. 27.

6: A5-A8). A more complete margin evaluation is a complex process and has to be specifically requested for each biopsy submission. The referring veterinarians may decide to ink only margins of concern where they suspect incomplete removal. Evaluation of surgical margins in anatomic pathology: technical, conceptual, and clinical considerations. Currently, breast cancer tumor margins are examined in a pathology lab either while the patient is anesthetized or after the surgical procedure has been terminated. However, on routine samples the evaluation is limited to the extent of the neoplasm on 2 cross sections.
PET-CT localized the primary tumor in fewer than half the cases. When such a tentacle is examined in cross section it can be very difficult to differentiate from reactive fibroblasts. Surgical margins are defined based on the surgeon’s experience, visual observation, and neuronavigation. Thus, histologic margin evaluation is not always definitive for these cases. Adjuvant treatment was based on final histopathology.The sensitivity of localizing the primary tumor with PET-CT was 50.9% with a specificity of 82.5%. The e-mail addresses that you supply to use this service will not be used for any other purpose without your consent.Create a link to share a read only version of this article with your colleagues and friends. Author Information The most commonly used method to evaluate tumor samples is the cross-sectioning method, also known as the radial method or “halves and quarters” (Fig. Nonetheless, … Find out about Lean Library If you have access to journal via a society or associations, read the instructions belowAccess to society journal content varies across our titles.If you have access to a journal via a society or association membership, please browse to your society journal, select an article to view, and follow the instructions in this box.Contact us if you experience any difficulty logging in.Some society journals require you to create a personal profile, then activate your society accountYou are adding the following journals to your email alertsDid you struggle to get access to this article? A decalcification fee is applied for bony tissues. This study compares positron emission tomography–computed tomography (PET-CT) findings with intraoperative identification of primary tumors and compares intraoperative frozen-section margins to final histopathology.

Ilan Z. Kafka & Timothy D. Averch. Marking margins of tumorectomies and excisional biopsies to facilitate histological assessment of excision completeness.

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